ASTX ASDs were further prepared with OSA-starch, HPMCAS-HF/Soluplus (R), and Span 20 as the wall materials. DSC, SEM, and XRD confirmed that crystalline ASTX had transformed to amorphous state in the ASDs, while FTIR spectra provided evidence suggesting the existence of hydrogen bonds and ...
Stability-enhanced hot-melt extruded amor- phous solid dispersions via combinations of soluplus(R) and HPMCAS-HF. AAPS PharmSciTech. 2015;16(4):824-34.Alshahrani SM,Lu W,Park JB,et al. Stability-enhanced hot-melt extruded amorphous solid dispersions via combi- nations of Soluplus(R) and ...
Physical properties and solubility studies of Nifedipine-PEG 1450/HPMCAS-HF solid dispersions.doi:10.1080/10837450.2018.1519573Rahul V HawareBhavani Prasad VinjamuriMonika GavireddiVivek S DaveDeepak GuptaMahavir B ChouguleWilliam C StagnerPharm Dev Technol...
The solubilities of NIF:PEG 1450:HPMCAS-HF SDs were significantly higher than their corresponding NIF:PEG 1450 SDs (p<0.0001-0.043). All the SD solubilities showed a statistically significant decrease (p<0.0001) after storage for five days. SDs PC were statistically lower than their comparable ...