In this study, a defatted ethyl acetate extract of Eremanthus crotonoides leaves with an inhibitory concentration (IC50) of 34.5 μg/mL towards α-glucosidase was investigated by high-resolution α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR. This led to identification of six...
High-resolution bioactivity profiling combined with HPLC-HRMS-SPE-NMR: 伪-Glucosidase inhibitors and acetylated ellagic acid rhamnosides from Myrcia palustris DC. (Myrta- ceae). Phytochemistry. 2015;116:246-52. doi:10.1016/j.phytochem.2015.04.004...
The high-resolution biochromatograms obtained by this technique were used to target subsequent structural elucidation by HPLC-HRMS-SPE-NMR analysis towards the bioactive constituents. This led to identification of 4-hydroxybenzoic acid (1) and 3-indolecarboxylic acid (6) associated with radical ...
Staerk DanMoleculesTrinh, B.T.D.; Jager, A.K.; Staerk, D. High-resolution inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of PTP1B inhibitors from Vietnamese plants. Molecules 2017, 22, 1228. [CrossRef] [PubMed]...