In this study, we present a comprehensive and validated workflow that combines the use of UHPLC-QTOF-HRMS instrumentation with a simple hair sample extraction procedure for the detection of a variety of fentanyl analogues and metabolites. A simultaneous targeted and untargeted analysis was applied to...
建立了测定硝苯地平中基因毒性杂质2,6和12的超高效液相色谱-静电场轨道阱高分辨质谱法(UHPLC-Orbitrap HRMS).样品以甲醇为溶剂,提取后直接进样分析.采用ACE EXCELTM 3... Changchuan Guo,Huijie Tan,Qi Liu,... - 《Chinese Journal of Chromatography》 被引量: 0发表: 2022年 HPLC/MS考察大鼠和肝微粒体...
LC-MS 将乙醇和DMSO提取物直接进样至配备BEH C18(1.7μm,2.1×100mm) 色谱柱的Waters ACQUITY UPLC I-Class-Waters Xevo G2-XS QTof(Waters Corp,Massachusetts,USA)LC-MS 系统中( 流速:0.5ml/min;进样体积:1μl;温度:40°C;流动相:A) 乙腈 | B) 含有10mmolNH4CH3COO 的水,梯度:0–0.5 分钟 5%...
(UHPLC-QTOF-MS) with sequential window acquisition of all theoretical fragment-ion spectra (SWATH) and was validated with forty-one compounds by spiking experiments in curry and paprika extracts. In order to detect and identify the compounds with a high level of confidence, a home-made tandem ...
Chemical constituents in Pegannum harmala based on UHPLC- QTOF-MS/MS and its neuroprotective activities [J]. Chin Tradit Herb Drugs, 2022, 53(6): 1688-1696. [21] 解鸿翔 . 信号分子 TRIF 的研究进展 [J]. 细胞与分子免 疫学杂志, 2012, 28(2): 217-220. Xie H X. Research progress of...
Estimation of target ions [M?+?H]+ at m/z 448.2455 for PAL and m/z 441.2044 for ibrutinib (IS) was performed in selective ion mode ESI–HRMS. Good sensitivity (1.0?ng/mL) and linearity over a wide concentration range of 1–2000?ng/mL was exhibited by the method. The results ...
They were identified based on EC and HRMS/MS information as well as the use of databases (Table 1). Furthermore, chemotaxanomic study indicates that these coumarins have already been identified in the Oleaceae family, especially in Lignans and triterpenic acids Lignans, another group of ...
第 42 卷第 17 期 韩忠耀 ,等: 基于 HPLC-HESI-HRMS 的水冬瓜根皮化学成分分析 · 17 · temperature was 40 ℃; HESI-II ion source was used for mass spectra, the date were collected in positive and negative mode.Mass scanning range m/z: 100~1500 Da.Compound discoverer 3.0 database and ...
UHPLC-MS/MS was carried out using Agilent 1290 infinity II connected to Agilent 6545 QTOF. HPLC column is ACE Excel C18 AR (100 × 2.1 mm, 1.7 µm) column. MS data were processed using MassHunter data acquisition software. ESI-HRMS spectra were acquired from Bruker MicroTOF mass spectrome...
Liquid chromatography in combination with high-resolution mass spectrometry (HRMS) has also been described for the identification and determination of phenolic compounds in vegetable oils [23,24,28,36]. Despite the number of applications described in the literature dealing with the determination of ...