The novelty in this manuscript is to describe the method development and validation of an assay to measure CBD and THC in plasma for pharmacokinetic studies when cannabis is used for medicinal purposes. Access through your organization Check access to the full text by signing in through your ...
Milk thistle is one of the most popular hepatoprotectants, and is often sold in combination with other ingredients. Botanical supplements are known to be vulnerable to contamination and adulteration, and emerging technologies show promise to improve thei
molecules Communication Development and Validation of a HPLC-UV Method for Extraction Optimization and Biological Evaluation of Hot-Water and Ethanolic Extracts of Dendropanax morbifera Leaves Hyung-Jae Choi 1,†, Dae-Hun Park 2,†, Seung-Hui Song 1, In-Soo Yoon 3,* ID and Seung-Sik Cho ...
molecules Article Development of a Unified Reversed-Phase HPLC Method for Efficient Determination of EP and USP Process-Related Impurities in Celecoxib Using Analytical Quality by Design Principles Tim Tome 1,2, Zdenko Cˇ asar 1,2,* and Aleš Obreza 1,* 1 Faculty of Pharmacy, University of...
pharmaceutics Article Development of a Column-Switching HPLC-MS/MS Method and Clinical Application for Determination of Ethyl Glucuronide in Hair in Conjunction with AUDIT for Detecting High-Risk Alcohol Consumption Yeon Gyeong Kim 1,†, Jihye Hwang 1,†, Hwakyung Choi 2 and Sooyeun Lee 1,*...
leaves and pods, a safety limitation of aloe-emodin and rhein was proposed, due to toxicological concerns. A quantitative, analytical method of the anthraquinone aglycones in all Ph. Eur. monographed herbal laxatives is of interest. A rational method development for the aglycones aloe-emodin, ...
3.2. Analytical Method Validation In terms of method validation, the system suitability and precision, limit of detection (LOD), limit of quantitation (LOQ), linearity and range, recovery, specificity, stress, robustness, and solution stability of this method for the analysis of the rasagiline ...
The analytical conditions were optimized in terms of the derivatization procedure, chromatographic condition, extraction procedure, and method validation according to EMEA guidelines. Once fully optimized, the method was applied to assess the SPT-inhibitory activity of the above-mentioned derivatives and ...
separations Article Biogenic Amines in Traditional Fiore Sardo PDO Sheep Cheese: Assessment, Validation and Application of an RP-HPLC-DAD-UV Method Claudia Zazzu 1, Margherita Addis 2, Marco Caredda 2, Maria Francesca Scintu 2, Giovanni Piredda 2 and Gavino Sanna 1,* 1 Dipartimento di Chimica...
2. Results and Discussion 2.1. Sample Preparation Sample preparation was a crucial step in method development for the analysis of AFs in different biological matrices of animal origin. High extraction recovery and limited matrix effects on the UHPLC-MS/MS instrument were desirable since AFs are exp...