Recurrent glioblastoma (rGBM) has no standard treatment. Despite a better molecular knowledge, few therapies have brought changes in clinical practice so far. Here we will review the current data evaluating the re-radiation, re-resection, bevacizumab, and cytotoxic chemotherapy agents in this setting...
Meisen WH and Kaur B: How can we trick the immune system into overcoming the detrimental effects of oncolytic viral therapy to treat glioblastoma? Expert Rev Neurother 13: 341-343, 2013.Meisen WH, Kaur B. How can we trick the immune system into overcoming the detrimental effects of ...
” Gonzalez-Aponte said. “Knowing that glioblastoma has daily rhythms, we immediately asked if time of day of DEX administration could explain these different findings, and it seems like it does.”
Glioblastoma (GBM) is the most common primary brain tumor in adults and remains very challenging to treat. In 2005, Stupp et al1 demonstrated a survival benefit in patients treated with radiation therapy to 60 Gy in 30 fractions with temozolomide after maximally safe neurosurgical resection, thereb...
A number of aggressive types of cancers have ways to protect themselves. Glioblastoma brain tumors and sarcomas consistently return because of these protective actions. GlioX works to stop them. These cancer cells have the ability to produce or turn on production of the QRPT enzyme. This enzyme...
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“Based on these insights, we are now developing drugs that can target and decrease expression of PRDM1-S in regulatory T cells,” Sumida said. “And we have initiated collaborations with other Yale researchers using novel computational methods to increase the function of regulatory T...
In myeloid leukemia and glioblastoma cells, inhibition of TETs enzymes decreases the levels of hm5c increases DNA methylation [15-18]. It is frequently reported that changes in DNA methylation levels regulate the expression of key enzymes in glycolysis. DNA methylation is also reported to cause ...
The anti-cancer molecule salinosporamide A, also called Marizomb, is inPhase III clinical trials to treat glioblastoma, a brain cancer. Scientists now for the first time understand the enzyme-driven process that activates the molecule. Researchers at UC San Diego’s Scripps Institution of Oceanog...
Understanding the genome at single-cell resolution across various human tissues has changed the way we look at human anatomy and has led to the discovery of new cell phenotypes. The genomic analysis of CTCs has similarly increased our understanding of tumour metastasis, intra-tumour heterogeneity and...