Indeed, simultaneous activation of oncogenic K-Ras and inactivation of the p53 tumor suppressor in mouse lung significantly accelerates the malignancy of the resultant adenocarcinoma.41 However, it remained unclear whether inactivation of p53 contributed to the initiation or progression of lung ...
And there it is: a simple way to challenge the dominant paradigm. Rather than wait until all risk has been effectively managed before taking action to overtake or get where we want to go, this sign encapsulates an attitude that says: “If we all want to achieve our objectives, and get w...
voicing:the vibration of the vocal folds.When the vocal folds are close together,the airstream causes them to vibrate against each other and the resultant sound is said to be“voiced”.When the vocal folds are apart and the air can pass through easily,the sound produced is said to be“voic...
A patent foramen ovale has been recognized as a potential intracardiac shunt in 20%–25% of the general population.83 However, the patency of the shunts during exercise will be resultant from the gradient of pressures manifested between the right and left atrium. As the pressure difference is...
separates a truly great puzzle game from the sort you poke at on your phone while taking a dump. What follows, then, is not a recipe so much as my extrapolated list of possible cooking utensils: approaches to consider which will radically alter the flavour and texture of the resultant ...
In his interview on CNBC today, Countrywide (cfc) CEO Angelo Mozilo said the analyst at Merill Lynch who put a “sell” on his company was “irresponsible” and not unlike yelling “fire in a crowded theater.” Sorry, Angelo, you are wrong. The analyst, who used to work at Countrywide...
With regard to the hyperammonemia of chronic liver disease: 1) shunting of portal blood around the liver, by itself, can account for commonly observed ammonia elevations; 2) severe portal hypertension causes an increased release of ammonia by the kidney; 3) high blood ammonia is associated with...
A trial employed phage training to produce a phage capable of overcoming this obstacle and following several transfer experiments the resultant ”trained” phage exhibited alteration in genes that encode phage receptor binding proteins. The mutation yielded a synthetic phage called PaoP5-m1, with a ...