For instance, the cumulative dose of radiation is a critical factor in longitudinal trials requiring repeated CCT measures, and contrast agents for CCT and CMR might be relatively contraindicated in patients with advanced kidney disease (eGFR < 30 mL/min).23,24...
This work describes the binding site and mechanism of action for small-molecule fusion inhibitors. Article CAS PubMed Google Scholar Samuel, D. et al. GS-5806 inhibits pre- to postfusion conformational changes of the respiratory syncytial virus fusion protein. Antimicrob. Agents Chemother. 59, ...
People with and without CKD are advised to engage in at least 150 minutes of moderate-intensity exercise per week. Exercise can be broken into 25- to 30-minute sessions, so you work out most days of the week.5 Exercise is moderate-intensity when you are breathing harder than normal and c...
Although numerous anti-cancer drugs have been developed, most cancers are still ultimately fatal due to the very high rate of recurrence. For example, gefitinib effectively eliminates EGFR- mutated lung adenocarcinomas at the beginning of therapy, but the cancers recur in 90% of patients within 2...
The T790M missense mutation occurs within the EGFR kinase domain and prevents binding of Gefitinib to this region while preserving catalytic activity [44]. In their study, the sampling interval used varied from 30 to 100 days, which corresponds to 2–7 bi-weekly cycles of chemotherapy [20]. ...
This receptor, known as epidermal growth factor receptor (EGFR), is overexpressed in many types of cancer. In fact, it is the target of several cancer drugs. Although these drugs often work well at first, tumors can become resistant to them. Understanding the mechanism of these receptors bette...
Trastuzumab(Herceptin), a breast cancer drug, is designed to treat women whose tumors have a protein called HER2. The drugscetuximab(Erbitux) andpanitumumab(Vectibix) target epidermal growth factor receptor (EGFR), a protein on the surface of some colon cancer cells that helps the cancer grow. ...
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I had some free time over the holidays and wrote this article to showcase, on the basis of a personal story, many highly actionable, science-based, approaches and tools that can be used to significantly enhance intelligence.
AXL, EGFR, and WNT5A have been associated with the resistant phenotype in melanoma and could be a potential mechanism of resistance [68]. These genes are expressed sporadically on single cell level prior to drug exposure, thus the cells that are capable of temporarily upregulating these genes ...