Lupus pathogenesis. Legend: Increase in apoptosis (A) and in NETosis (B) and decreased capacity to dispose apoptotic residues (C) leads to increased auto-antigen exposure. These auto-antigens bind to stochastically generated autoantibodies, forming immune-complexes. Plasmacytoid dendritic cells (pDC)...
When time is up, they update their destination variable (i.e. destination = origin) and travel back to their origin, where they are eventually removed from the simulation. Download: Download high-res image (252KB) Download: Download full-size image Fig. 3. Model’s schedule showing actions...