Dunn, Bill
Abstract IA27: Retooling CRISPR to turn genes on and off CRISPR (clustered regularly interspaced short palindromic repeats) is an adaptive genome defense system in bacteria and archaea. CRISPR has been widely repurposed as an RNA-guided genome editing method. We have shown that the endonucleas....
such as a biofuel, you have to alter the metabolism of an organism. This requires overexpressing genes that lead to production and turning off genes that compete with production. Our system allows researchers to turn off genes in a way that...
PlayDownload Question What does it actually take to turn off a defective gene? Answer We put this question to Adrian Thrasher from Great Ormond Street Hospital: Well, usually we don't need to turn off a defective gene because the nature of the mistake is usually such that the gene is off...
identified the domestic chicken (Gallus gallus domesticus) as a domesticated subspecies of the red junglefowl (Gallus gallus), Swedish researchers ina 2008 studyidentified early crossbreeding with the grey junglefowl (Gallus sonneratii) as introducing the genes behind the modern chicken's yellow legs....
They might add genes to the ones they were born with, or they might tinker with how the body uses the genes they have. Gene doping is an unintentional spin-off of gene therapy in which, doctors add or modify genes to prevent or treat illness. Gene doping would apply the same ...
An international team of biologists has discovered how specialized enzymes remodel the extremely condensed genetic material in the nucleus of cells in order to control which genes can be used. The discovery will be published in the print edition of the j
Although this was the first example of an embryo’s genes being changed successfully, the advantages of gene editing have already been tested in living patients. In 2015, a five-month-old girl from the UK was saved after doctors used edited cells to fight off her cancer. As of today, she...
This change often deactivates the gene, making CRISPR editing a simple strategy to switch off genes. Scientists have also modified the Cas9 enzyme to make other types of edits. By disabling Cas9's genetic scissors and then fusing this "dead Cas9" to another enzyme, they can rig the ...
We refer to two genes as alleles of each other when they are inherited as alternatives to each other. In molecular terms, alleles are different forms of the same gene. There can be more than two alleles of a gene in a population of organisms. But any given organism has only two alleles...