Comparing to a generic two-state model, our models can distinguish class I from class II MHCs and correlate their structural parameters with the TCR/pMHC’s potency to trigger T cell activation. The models are tested by mutagenesis using an MHC and a TCR mutated to alter conformation changes....
We have presented here cryoEM structures of two MAC conformations and derived an atomic model for the transmembrane complex. Furthermore, we have shown corroborating flicker spectroscopy data that explain how MAC assembly precursors alter physical properties of the membrane to prime the bilayer for att...
The pricing structure is simple: $85,000 for a cloned horse, $50,000 for a dog, and $35,000 for a cat. There are also more affordable options for cryopreserving biopsy samples of your pet ($500), which essentially puts your pet’s genetic info on file in case you decide to clone...
The researchers found that the GPCR turns on an E3 ligase, the very enzyme that does the ubiquitinating, which triggers a cascade of molecular events that ultimately turn on another protein, p38, which in turn promotes inflammation. According to Trejo, a handful of drugs that inhibit E3 ubiqu...
Fungi have been companions of mankind for millennia. Mushrooms inspired our eating culture, and yeasts and filamentous fungi were developed into highly efficient cell factories during the last 100 years to produce many products utilized in different indu
The visual inspection of simulation trajectories shows significant conformational flexibility of the TGs in CETP tunnel. To quantify the conformational changes, we first defined suitable vector on each oleate chain in TG. The vectors were constructed originating from the central carbon, C, of the TG...
Comparing to a generic two-state model, our models can distinguish class I from class II MHCs and correlate their structural parameters with the TCR/pMHC’s potency to trigger T cell activation. The models are tested by mutagenesis using an MHC and a TCR mutated to alter conformation changes....