Comparing to a generic two-state model, our models can distinguish class I from class II MHCs and correlate their structural parameters with the TCR/pMHC’s potency to trigger T cell activation. The models are
We have presented here cryoEM structures of two MAC conformations and derived an atomic model for the transmembrane complex. Furthermore, we have shown corroborating flicker spectroscopy data that explain how MAC assembly precursors alter physical properties of the membrane to prime the bilayer for att...
The research strategy which included Mesh word and free word is as followed: (((ablation therapy) or (ablation) or (radiofre- quency) or (radiofrequency therapy)) or ((laser) or (laser*)) or ((microwaves) or (microwave*) or (MWA)) or ((cryoabla- tion*) or (cryosurgery*) or (...
Fungi have been companions of mankind for millennia. Mushrooms inspired our eating culture, and yeasts and filamentous fungi were developed into highly efficient cell factories during the last 100 years to produce many products utilized in different indu
[26,27,28]. In this regard, a recent study applied cryo-electron tomography to four procentriole cartwheels of human cells (note that mature human centrioles lack cartwheels) in order to determine the cartwheel length and to better understand the relationship between the A–C linker and the...