The survival benefit conferred by this agent, along with its marked efficacy with regard to spleen volume and symptom reduction, have made ruxolitinib the cornerstone...doi:10.1097/01.COT.0000514187.87553.3aBose, PrithvirajVerstovsek, Srdan
Advanced systemic mastocytosis (SM) is a rare myeloid neoplasm characterized by uncontrolled accumulation of neoplastic mast cells (MCs) in various organs with consecutive impairment of organ function, drug resistance, and a poor prognosis. Advanced SM may present as smoldering or slowly progressing ne...
When to Suspect and How to Diagnose and Treat Pediatric Cutaneous and Systemic MastocytosisCarterAaaai
Summary: Mastocytosis constitutes the neoplastic proliferation of mast cells and is broadly classified into systemic mastocytosis (SM), cutaneous mastocytosis and mast cell sarcoma. SM is further partitioned into advanced (AdvSM) and non‐advanced (SM‐non‐Adv) subcategories. AdvSM includes...
How to diagnose and treat mastocytosis: the predominant presentation of this mast-cell disorder is development of pruritic lesions--especially after rubbing or exposure to heat.(FEATURE)Weinberg, Jeffrey M
Valent P., Sperr W.R., Akin C. How I treat patients with advanced systemic mastocytosis. Blood 2010; 116 (26): 5812--5817.Valent P, Sperr WR, Akin C: How I treat patients with advanced systemic mastocytosis. Blood 2010, 116:5812-5817....