Nontransplant Treatment Options for Myelofibrosis: How to Treat Anemia, Splenomegaly, Constitutional Symptoms, and Extramedullary DiseaseCurrent drug therapy in PMF is not curative and has not been shown to prolong survival. Allogenic stem cell transplant (ASCT) is potentially curative but also ...
ITP remains a diagnosis of exclusion due to the lack of a “gold standard” diagnostic test. History taking, physical examination, complete blood count, and peripheral blood film assessment are the basic workups for suspected patients. Splenomegaly and constitutional symptoms (e.g., fever, weight...
How I treat polycythemia vera Polycythemia vera (PV) is a chronic myeloprolifera Vannucchi,M A. - 《Blood the Journal of the American Society of Hematology》 被引量: 0发表: 2014年 How I treat symptomatic splenomegaly in patients with myelofibrosis. Managing patients with myelofibrosis (MF), eit...
The number of HSCTs for MF continues to increase worldwide, but its inherent therapy-related morbidity and mortality limit its use for many patients. Furthermore, patients with MF often present at an older age, with cytopenia, splenomegaly, and severe bone marrow fibrosis, posing challenges in ...
ITP remains a diagnosis of exclusion due to the lack of a “gold standard” diagnostic test. History taking, physical examination, complete blood count, and peripheral blood film assessment are the basic workups for suspected patients. Splenomegaly and constitutional symptoms (e.g., fever, weight...
(Fig.1e–g). Notably, these sites are also where nasal NK/T-cell lymphomas metastasize to. In < 5% of cases, the lymphoma may be disseminated on presentation with hepatosplenomegaly, lymphadenopathy, marrow involvement, and a leukaemia phase. These disseminate cases are referred to ...
and personal history of cancers, drug and alcohol use, bleeding problems, and other medical conditions (rheumatic diseases, liver problems,kidney disease) needs to be included in this evaluation. Anenlarged spleen(splenomegaly), petechiae, and purpura are typically looked for on the physical examinati...
A 51-year-old woman presented to our hospital with easy bruising for 1 week, combined with heavy menses, weight loss, and increasing fatigue over 2 months. Physical examination was noteworthy for pallor and splenomegaly. Laboratory evaluation showed a white blood cell count of 56 × 109/L, he...
A whole-body computed tomograpy scan was negative for splenomegaly or lymph node enlargement, thrombosis, and infectious lesions. Normal coagulation parameters and absence of schistocytes excluded disseminated intravascular coagulation and other microangiopathies. The patient was transfused and treated ...
Complications related to BTs are due to chronichemolytic anemia, if not corrected, and include poor growth, jaundice from hemolysis,hepatosplenomegaly, andextramedullary hematopoiesis. Regular transfusions lead to iron overload, which may result inendocrine disorders,cardiomyopathy, and cirrhosis, among ot...