Nontransplant Treatment Options for Myelofibrosis: How to Treat Anemia, Splenomegaly, Constitutional Symptoms, and Extramedullary DiseaseCurrent drug therapy in PMF is not curative and has not been shown to prolong survival. Allogenic stem cell transplant (ASCT) is potentially curative but also ...
ITP remains a diagnosis of exclusion due to the lack of a “gold standard” diagnostic test. History taking, physical examination, complete blood count, and peripheral blood film assessment are the basic workups for suspected patients. Splenomegaly and constitutional symptoms (e.g., fever, weight...
The number of HSCTs for MF continues to increase worldwide, but its inherent therapy-related morbidity and mortality limit its use for many patients. Furthermore, patients with MF often present at an older age, with cytopenia, splenomegaly, and severe bone marrow fibrosis, posing challenges in ...
It is rare to have a presentation ofglandular fever in those over the age of 40 and glandular fever in this age group may present without a sore throat or lymphadenopathy. Older adults are less likely to have splenomegaly. Can I kiss my girlfriend if she has mono? It is advisable to at...
A 51-year-old woman presented to our hospital with easy bruising for 1 week, combined with heavy menses, weight loss, and increasing fatigue over 2 months. Physical examination was noteworthy for pallor and splenomegaly. Laboratory evaluation showed a white blood cell count of 56 × 109/L, he...
and personal history of cancers, drug and alcohol use, bleeding problems, and other medical conditions (rheumatic diseases, liver problems,kidney disease) needs to be included in this evaluation. Anenlarged spleen(splenomegaly), petechiae, and purpura are typically looked for on the physical examinati...
splenomegaly No new signs or symptoms of active disease PD X25% increase in serum IgM level from lowest nadir and/or Progression in clinical features attributable to the disease Abbreviations: CR, complete response; MR, minor response; PD, progres- sive disease; PR, partial response; ...
In hemolytic anemia,jaundice and hepatosplenomegalyare often seen mimicking liver diseases. In hematologic malignancies, malignant cells often infiltrate the liver and may demonstrate abnormal liver function test results accompanied by hepatosplenomegaly or formation of multiple nodules in the liver and/or ...
Immunodeficiency and infection HLHa (due to EBV, CMV, and other infections) ++ ++ 3,29,36, 69,70 Splenomegaly Hypo- or dysgammaglobulinemia Severe or fulminant infectious mononucleosis (due to EBV) +/− ++ ++ ++ + ++ 3,36 12,70 12,53 Intestinal Crohn-...
On abdominal examination, the spleen measures 10 cm below the left costal border, and he is diffusely tender to palpation throughout the abdomen. An abdominal computed tomography scan shows splenomegaly and no evidence of portal or mesenteric vein thrombosis. Examination of the extremities is un...