CDK4/6 inhibitors in association with endocrine therapy represent the best therapeutic choice for either endocrine-sensitive or resistant hormone-receptor-positive advanced breast cancer patients. On the contrary, the optimal therapeutic strategy after the failure of CDK4/6 inhibitors-based...
Foods to eat and avoid for HER2+ patients and survivorsFoods to eat and avoid for inflammatory breast cancer patients & survivorsAll breast cancer patients should take into account their ER/PR subtype in designing their diets:Hormone receptor positive (ER+/PR+) breast cancer...
Approximately 20 percent of breast cancers are HER2+, meaning they over-express the HER2 gene, resulting in a particularly aggressive form of the disease.4 The first targeted treatment approved to treat HER2+ breast cancer was Herceptin® (trastuzumab) “” in which the BCRP provided...
How would you describe the development and changes of a breast during a woman’s life with a specific nod to how this will factor into helping us understand the pathology of breast cancer development during some of those stages? The breast is a gland ...
HER2-positive.A gene called human epidermal growth factor receptor 2 (HER2) makes HER2 protein. These proteins act as receptors. Some breast cancer cells make too many HER2 proteins. When this happens, the cells grow faster than usual.
Management requires combined modality therapy, including neoadjuvant chemotherapy with an anthracycline and taxane-based regimen, followed by surgery and radiotherapy, plus concurrent anti-HER2 therapy for HER2-positive disease, and endocrine therapy for at least 5聽years after surgery for estrogen-receptor...
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Breast cancer that expresses HER2 is known as HER2-positive and HER2-low depending on how many HER2 proteins are on the cells. These types of breast cancer may be able to be treated by Enhertu (fam-trastuzumab deruxtecan-nxki). In most cases, you will have to have tried another HER2-...
Explore the latest treatments for metastatic breast cancer, including hormone therapy, chemotherapy, and immunotherapy, tailored to specific types and subtypes.
Tumors known to have a high frequency of NTRK fusions, such as secretory breast carcinoma, should always be evaluated for the presence of this molecular driver using RT-PCR or FISH as initial methods. For tumors with a low pretest probability of a positive result (e.g., breast cancers in...