Regulatory T cell-enhancing therapies to treat atherosclerosis. Cells 10, 723 (2021). Article CAS PubMed PubMed Central Google Scholar Mauersberger, C., Schunkert, H. & Sager, H. B. Inflammation-related risk loci in genome-wide association studies of coronary artery disease. Cells 10, 440...
Primary immune thrombocytopenia (ITP) is an immune-mediated bleeding disorder characterized by decreased platelet counts and an increased risk of bleeding. Multiple humoral and cellular immune abnormalities result in accelerated platelet destruction and
Intravenous immunoglobulin (IVIG) therapy is used to treat immunodeficient patients, but it can also suppress various autoimmune and chronic inflammatory diseases. Despite the clinical success of IVIG therapy, its mechanisms of action remain controversia
In fact, splenectomy has poor effectiveness in AIHA secondary to systemic autoimmune disorders and immunodeficiencies.49 Recently, the availability of molecular tools has increased the chances of identifying these forms early: mutations in KDM6A or KMT2D have been identified in Kabuki syndrome, and ...
The decrease in peripheral blood platelet count of ITP patients results from accelerated platelet clearance and impaired platelet production. The loss of immune tolerance to platelet autoantigens is the critical upstream step in ITP pathophysiology, which leads to the abnormal recognition of platelet aut...
Meisen WH and Kaur B: How can we trick the immune system into overcoming the detrimental effects of oncolytic viral therapy to treat glioblastoma? Expert Rev Neurother 13: 341-343, 2013.Meisen WH, Kaur B. How can we trick the immune system into overcoming the detrimental effects of ...
11 The immune system during pregnancy is altered to accommodate a fetus whose genetic make-up is half paternal.12 There is reduced activity of natural killer cells, inflammatory macrophages, and helper T-cell type 1 cells, and reduced production of inflammatory cytokines.12 Infections that are ...
Researchers at The University of Texas MD Anderson Cancer Center have discovered how an aggressive form of prostate cancer called double-negative prostate cancer (DNPC) metastasizes by evading the immune system. The investigators also reported on the pre-clinical development of a new therapy, which...
Ordaōs is developing a class of miniproteins with enhanced biological and therapeutic attributes to treat uniquely challenging rare cancers that primarily afflict ethnic minorities.. Absci is using deep-learning AI and synthetic biology to design new antibodies against cancers and immune diseases. ...
SBRT treats early-stage lung cancers that are small and haven't spread beyond the lungs. This type of therapy may also be used to treat early-stage tumors that come back. Radiofrequency ablation (RFA) RFA creates heat using high-energy radio waves to kill cancer cells. It's delivered with...