AL, light chain amyloidosisATTR, transthyretin amyloidosisFLC, free light chainIFE, immunofixation electrophoresisKLR, kappa:lambda ratioPyP, technetium pyrophosphateSFLC, serum free light chainSPEP, serum protein electrophoresisUPEP, urine protein electrophoresisamyloidosis...
20 These numbers are expected to be far less in general medical practice. We also look for monoclonal gammopathy if a patient has a nonmalignant disease known to be a cause of, or associated with, monoclonal gammopathy, especially if the treatment requires control or eradication of the plasma ...
Allpatientsdiagnosed with myeloma, a cancer of the blood-producing bone marrow, first develop a relatively benign condition called 'monoclonal gammopathy of undetermined significance' or 'MGUS'. MGUS is fairly common in the older population and only progresses to cancer in approximately one in 100 c...
Quantitative ImmunoglobulinsThis test measures the levels of different kinds of antibodies in the blood. Multiple myeloma can raise or lower levels of certain antibodies. This is the umbrella term for a variety of tests that can detect monoclonal antibodies in a blood or urine sample. Serum-Free ...
How to resolve a clinical and molecular puzzle: concomitant monoclonal gammopathy of undetermined significance (MGUS) with neutrophilia and clonal hematopoiesis of indeterminate potential (CHIP)doi:10.1007/s00277-019-03786-9Simon HaefligerInstitute of PathologyDarius Juskevicius...
How I treat monoclonal gammopathy of renal significance (MGRS). Blood 2013;122:3583-3590. [2] Zheng F, Zhao S, Li X. [The clinical and biochemical manifestations of Fanconi syndrome: a report of 42 cases]. Zhonghua Nei Ke Za Zhi 2000;39:735-738....
Recently, the term monoclonal gammopathy of renal significance (MGRS) was introduced to distinguish monoclonal gammopathies that result in the development of kidney disease from those that are benign. By definition, patients with MGRS have B-cell clones that do not meet the definition of multiple ...
Summary Significant advances have been made in our understanding of the natural history, pathogenesis, mechanisms of progression and prognosis of monoclonal gammopathy of undetermined significance (MGUS). Although the overall incidence of MGUS progression is 1 per year, it is now...
Risk stratification by free-light chain (FLC) ratio, immunoglobulin (Ig) type, and serum monoclonal(M) protein level is warranted. Low-risk patients should have SPEP every 2 to 3 years, while patients with higher-risk MGUS should have SPEP every year (SOR: C, expert opinion)....
63 In the remainder, CAD is commonly associated with an underlying clonal B-cell disorder similar to WAIHA. In a recent series of non–infection-related CAD patients (N = 89), 34% were found to have a B-cell lymphoma, and another 47% had monoclonal gammopathy of undetermined significance....