We studied general and cancer related distress in 85 healthy women with a 25% or 50% risk of being carrier of aBRCA1/BRCA2 gene mutation and 66 partners in the six to eight week period between genetic counselling/blood sampling and disclosure of the test result. Questionnaire and interview ...
To test the idea, Park’s team first selected cell lines derived from non-cancerous human breast epithelial cells – where BRCA1 breast cancers originate. They then used an advanced gene-targeting technique to create new cell lines that have a typical cancer-linked BRCA1 mutation in only one ...
Researchers in this study wanted to understand how mutations in the gene that codes for the estrogen receptor, ESR1, can contribute to fulvestrant resistance. They found that in 4% of patients, following fulvestrant treatment, their breast cancer developed specific mutations in the ESR1 gene, called...
“If a person has a cancer of a certain type at a certain age or they have a strong family history, then we test them — that is critical. I strongly recommend testing for everyone who meets the guidelines, and within a few years we’re just going to test everybody.” Hughes and hi...
Relationship of sense of coherence to stressful events, coping strategies, health status, and quality of life in women with breast cancer ObjectiveTo test the hypothesis that Antonovsky's concept of sense of coherence (SOC) predicts stressful events, coping strategies, health status, and qual... ...
Results can help you understand your risk of getting breast and ovarian cancers and steps you can take to reduce your risk. A positive test result does not mean you will definitely get breast or ovarian cancer. If you...
It is likely that the ORFs encoding such proteins are also antisense to existing genes. In this study, we analyse the emergence of ORFs in antisense RNAs. We specifically focus on ORFs that have an antisense overlap with the coding region (canonical ORF) of an existing protein coding gene. ...
Results can help you understand your risk of getting breast and ovarian cancers and steps you can take to reduce your risk. A positive test result does not mean you will definitely get breast or ovarian cancer. If you test negative for a specific gene mutation, you still may be at an inc...
The semi-structured interview had five sections: genetic testing experience, impact, and interpretation of the test result, deciding whether to communicate test results to family members, impact of communication on family members, and suggestions for genetic counselors and other PCA patients. Interviews...
University of Oregon biologists have uncovered a mechanism by which a well-known breast cancer gene also influences fertility. Mutations in the BRCA1 gene sharply increase a person's risk of developing breast cancer, and BRCA1 patients often face fertili