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High-dose melphalan and autologous stem cell transplantation (HDM) is an effective treatment for systemic amyloid light chain (AL) amyloidosis but the eligibility criteria exclude many patients with this disorder. The aim of this study was to determine appropriate treatment strategies for systemic AL ...
Calculated globulin (CG) isderived from the difference between total protein and albumin results, and forms part of the liver function test (LFT) profile. CG is used widely in primary and secondary care to detect high levels that may indicate haematological malignancy, such as multiple myeloma. ...
non-coding double-stranded pieces of RNA that can silence specific genes. In 2012, the biotech company Alnylam Pharmaceuticals started clinical trials of patisiran, a siRNA drug that treats hereditary transthyretin-mediated amyloidosis, a neurodegenerative disease caused by ...
This measures how the adrenal glands respond after taking a dose of adrenocorticotropic hormone. If the glands produce little cortisol after the medicine, they may not be working properly. A blood test will need to be done to measure cortisol levels. ...
it means that only patients suffering from lymphoma-related symptoms should start treatment.25 In the case of WM, this includes symptoms caused by circulating IgM paraprotein, such as hyperviscosity, amyloidosis, symptomatic cryoglobulinemia, cold agglutinin disease, and neuropathy or disease-related hemo...
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(Health Care Exchange) plan, you may still be qualified to receive and use this savings card. Please note: the Federal Employees Health Benefits (FEHB) Program is not a federal or state government health care program for purposes of the savings program. Void where prohibited by law. There ...
Although HCM is typically symmetrical in FD,24 the common occurrence of fibrosis and thinning of the posterior wall with loss of the symmetrical LVH pattern at the HCM stage (≥15 mm)24,46 make, together with the existence of this LVH pattern in other phenocopies (amyloidosis, mitochondrial ...
This article details the more operational aspects of monograph submissions, answering the question of how to participate. This question, in turn, is best approached by considering the following: who in the company is responsible for monograph submission and follow-up; what information and materials ...