It is nearly always possible to document the expression of CD138-positive plasma cells in WM by either immunohistochemistry or flow cytometry.17 However, expression of CD5, CD10 and CD23 may be found in 10–20% of cases, and does not exclude the diagnosis of WM.18 According to the WHO...
This study focuses on a selection of seven popular clustering approaches based on diverse underlying principles which are described in more detail in the methods section. With K-means [36] and Partitioning Around Medoids (PAM) [37], the two well-established non-hierarchical clustering methods were...
In this study we provide strong evidence that mesothelioma might be caused by conditions that trigger chronic inflammation where activation of YAP/TAZ signaling, RNA editing, and a tumor-promoting environment appear prior to tumor development. The RNA editing signature downstream ADAR activity is sugges...
The availability of rodent species chromosome painting probes as well as the information obtained by the comparative karyotype and comparative gene mapping data are of great interest to improve knowledge on species evolution but also to better understand carcinogenesis process, as illustrated by our data...
cells that harbor this stem-cell-like function. "These cells are like the fountain of youth for T cell immunity, allowing exhausted T cells to self-renew and remain functional," says Dr. Lorenz Kretschmer a postdoctoral researcher in Dr. Buchholz's lab, and co-first author of the study. ...