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A study was conducted by Zhang et al., to illustrate the role of T-type channels in glioma stem cells. The authors used mibefradil and shRNA with cytotoxic therapies to inhibit the T-type calcium channels. That downregulated the growth, stemness of glioma stem cells and diminished its ...
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Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochem... Prostate cancer is an androgen-dependent disease; metastatic prostate cancer is typically treated by androgen receptor (AR) blockade. Recurrence after...
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- 《Biochem Soc Symp》 被引量: 121发表: 1999年 Time-dependent mitochondrial-mediated programmed neuronal cell death prolongs survival in sepsis. To investigate whether apoptosis is a possible mechanism of brain dysfunction occurring in septic syndrome.Experimental prospective study.Laboratory of Sur......
Topoisomerase activity is indispensible to cells, but requires the transient breakage of DNA strands. This property has been exploited, often for significant clinical benefit, by various exogenous agents that interfere with cell proliferation. Despite decades of study, surprising findings involving ...