Pomalidomide and dexamethasone -- shown to kill cancer cells and stop them from multiplying Bortezomib and pegylated doxorubicin -- significantly reduces risk of disease progression by 45%. (Peripheral neuropathy related to bortezomib happens in almost half of cases.) Carfilzomib alone or with dexametha...
Gluconeogenesis (Latin for “The making of new sugar”) is the process where the liver converts protein to glucose. This goes on all the time to some extent but is suppressed in the presence of adequate amounts of insulin and drinking alcohol. In type one patients who are no longer able ...
(ORR), which measured the percentage of people who had a response to therapy. It also looked at how long it took people to respond (time to response), how long the response lasted (duration of response), and how long people stayed alive without progression of their cancer (progression-...
Oxidative stress is an imbalance between free radicals (reactive oxygen species/ROS) and antioxidants that neutralize them. Free radicals play anessentialrole in biological processes, but excessive ROS cause cellular and DNA damage. Edaravone acts as anantioxidant, and delays disease progression by scav...
ARTICLE Spinocerebellar ataxia: Patient and health professional perspectives on whether and how patents affect access to clinical genetic testing Ashton Powell, PhD1, Subhashini Chandrasekharan, PhD2, and Robert Cook-Deegan, MD2 Abstract: Genetic testing for spinocerebellar ataxia is used in diagnosis ...
Diabetes: Diabetic Peripheral Neuropathy Treatment This nerve damage is a common complication of both type 1 and type 2 diabetes. Find out how to prevent it, slow its progression,... Slideshow: Diabetes Management in 10 Minutes Learn 10 simple ways to better manage your diabetes. See tips for...
However, long-term treatment and the adverse events associated with the treatment of DR-TB are still problematic. To solve these problems, optimal treatment regimens designed/tailor-made for each patient are necessary, regardless of the location in the world. In contrast to TB, NTM infections ...
The purpose of this review is to accelerate the work in the field and motivate progression towards presenting the mechanism-based antipruritic action of BoNTs, which can potentially strengthen, accelerate, and facilitate their approval for itchy conditions. 2. Clinical Evidence for the Use of BoNT...
, both type 1 andtype 2 diabetes. Diabetic macular edema is a major contributor to several cases ofblindnessin the United States. The retina is the part of the eye located at its back. It is the junction where the eye signals are converted to visual signals and carried through the optic...
The primary endpoint was freedom from first progression, favoring BEACOPPesc with a 7-year freedom from progression rate of 85% and 73%, respectively (p = 0.004). However, there was no difference in event-free survival (EFS). This lack of EFS may be attributed to high acute toxicity, ...