The high number of DNA-vaccines tested in clinical trials emphasizes their important role for future medical approaches. This review aims to summarize current achievements and ongoing developments in the design of optimized DNA vaccines and delivery methods. 2. Course of Action of DNA Vaccines The ...
Cells are constantly subjected to DNA damage and all organisms, including plants, have evolved efficient mechanisms for sensing this damage (Figure 2). Two key factors involved in the recognition of DNA lesions are ATM (Ataxia Telangiectasia Mutated) and ATR (ATM and Rad3-related), protein kinas...
NPC1L1 is a polytopic transmembrane protein and is the key molecule for this process [35]. Disruption of the coding gene reduces cholesterol absorption by half in mice [35]. This transporter resides in the intestinal BBM and internalizes upon exposure to cholesterol on the apical membrane in ...
To do so, it first undergoes conformational changes that partially uncoat the virus. This conformational change generates a hydrophobic viral particle that binds to and inserts into the ER membrane, a step required for successful membrane transport. Multiple PDI family members impart SV40 structural ...
In this review; we first describe the domain architectures of proteins harbouring G-type; L-type; LysM and malectin carbohydrate-binding domains. We then focus on the functions of LecPs; LecRLKs and LecRLPs referring to the biological processes they are involved in and to the ligands they ...
education sciences Article How to Align the University Curricula with the Market Demands by Developing Employability Skills in the Civil Engineering Sector Livia Anastasiu 1,*, Alexandra Anastasiu 2, Mihaela Dumitran 1, Codru¸ta Crizboi 1, Alexandra Holmaghi 1 and Maria Nicoleta Roman 1 1 ...
Instead, it binds to fully hydroxymethylated and hemi-hydroxymethylated DNA 3.2- and 1.5-fold more tightly than it does to hemi-methylated DNA, respectively. In addition, the Chromatin target of Prmt1 (CHTOP)-methylosome complex, which methylates H4R3, has been recently described as a novel ...