750g of toluene was charged to a reaction vessel under a nitrogen atmosphere. 335g of 2-chloronicotinic acid was added with stirring at room temperature. 35g of dimethyl formamide (DMF) was added to the mixture, and the resulting reaction mixture was slowly heated to 40℃ with stirring. 300...
Step 2: Transfer the resin from step 1 to a reaction column and swell it in DCM. Use 20% PIP/DMF to remove Fmoc. Wash with DMF and DCM alternately. Test with ninhydrin, and the result should be positive. Dissolve Fmoc-Trp(Boc)-OH and HOBT in DMF/DCM=3/1 as the reaction solvent....
Figure 1: Synthesis reaction of PHTHALIMIDOACETALDEHYDE DIETHYL ACETAL Experimental Procedure:Method 1:Mix phthalic anhydride and aminoacetaldehyde diethyl acetal, then quickly add the mixture to a preheated reaction vessel. Stir and heat until the mixture melts, then maintain the reaction temperature....
You should be able to monitor is by looking for the loss of TMS by GC or GC/MS.This reaction is going to be rather water sensitive in my view. It also creates water, so you will need a setup to continuously remove it from the system. Unfortunately KOH and DMF are just about some ...
One of the most important chromatographic success factors is sample solubility. If one or more compounds in your reaction mixture is insoluble in the method’s mobile phase, there is a good chance they will precipitate, even during injection into an equilibrated column. To ensure this does not ...
(home-made TiO2nanoparticles: average particle size is around 50 nm, crystalline phase is anatase) films were spin-coated onto the bl-TiO2/FTO substrate and were calcined at 500 °C for 1 h in air to remove the organic portion. To fabricate efficient perovskite cells based on the (...
Knowing that complexes 6M were only poorly soluble in DMF, we used complexes 7M as precatalysts for the Mizoroki–Heck coupling reaction between iodobenzene and styrene. The catalytic experiments were conducted in DMF at 120 °C with 1 equiv. of iodobenzene, 1.1 equiv. of styrene, 2 equiv. ...
The VW VR6 motor is known to run hot... very hot. Oil temperatures of 250F aren't out of the norm and really should not be a cause for panic. That said, the MKV R32 has an issue with overheating on the track when... 67 26K dmfracer replied Dec 14, 2016 ...
(including the final reaction mixture at 72 h) were boiled for 5 min to stop the reaction and then filtered using a 96 well filter plate with 0.2 µm PES membrane installed on a vacuum manifold (Merck Millipore). Soluble oxidized products were quantified from the filtrate using HPAEC as ...
The peptide resin was washed with DMF (3 × 30 s) and DCM (3 × 30 s). The peptide was cleaved from the resin and sidechain deprotected using TFA/water/TIPS (4 mL, 95:2.5:2.5) for 3 h and collected in a 50-mL centrifuge tube. The cleavage reaction was repeated for 10 min. ...