Santos RD et al (2015) Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: results of 4 phase III trials. Arterioscler Thromb Vasc Biol 35(3):689–699 Article CAS PubMed PubMed Central Google Scholar Chiriboga...
The responsible gene was found to be microsomal triglyceride transfer protein (mtp), a protein essential for the biosynthesis of apolipoprotein B (ApoB)-containing lipoproteins (Avraham-Davidi et al., 2012). Mtp functions non-autonomously and it was found that ApoB suppresses angiogenesis, but ...
Of note, recent studies also identified apolipoprotein C3 as a signal for alternative inflammasome formation [149]. By uncoupling inflammasome activation from lytic cell death, alternative inflammasome activation consequently provides a platform for sustained inflammatory signaling that may provide adequate ...
The lack of clinical benefit from pemafibrate has emphasised the concept that lowering TG levels is not sufficient to reduce the CV risk unless it is accompanied by a reduction in the number of circulating atherogenic lipoproteins, which can be assessed by determining apolipoprotein B levels. ...
Atherogenesis from diets high in total and saturated fat and cholesterol may relate to increases in plasma total, low- or very low-density lipoprotein cholesterol or triglycerides, or decrease in high density lipoprotein cholesterol, or altered apolipoproteins. A variety of dietary manipulations can ...
Citation47 The most common biological markers for macrophages are scavenger receptors, including type A and type B scavenger receptors,Citation48 while apolipoprotein A1-derived peptides, which mimic LDL, are also common ligands for targeting macrophages.Citation49 Therefore, inhibiting macrophage ...
The human APOE gene encodes apolipoprotein E (apoE), with three isoforms: apoE2, apoE3 and apoE4. Sex is the other universal biological variable of AD, as females exhibit an almost two-fold greater lifetime AD risk and greater dementia burden compared to males (Barnes et al., 2005; ...
Lp(a)consists of an LDL-like core lipoprotein molecule but differs from other lipoproteins as it contains a unique apolipoprotein(a) or apo(a)(2). Similar to LDL, an Lp(a) particle also contains one molecule ofapolipoprotein B (apoB). ...
Together with pycnogenol, nattokinase was found to reduce leg edema and venous blood clots in long-haul air travelers. B vitamins. Vitamin B12 and folic acid deficiencies cause high homocysteine levels, which have been associated with increased atherosclerosis, stroke, arterial clots, and venous ...
Bempedoic acid is a novel therapeutic agent that is designed to reduce levels of low-density lipoprotein cholesterol (LDL-C). The purpose of this review is