HSC-derived monocytic cells obtained from human and mouse BM were found to reduce Aβ burden by phagocytosis in AD transgenic mice [86]. BMDCs, much like microglia, are clearly attracted to amyloid plaques (Fig. 2). We have recently shown that chemokine receptor 2 (CCR2)-expressing myeloid...
forms harmful filaments more easily when its ends are cut off, and that its flexibility contributes to the varied shapes of these filaments. They’ve identified a sequence of amino acids that could be targeted by drugs to prevent the formation of these filaments. ...
The sticky amyloid beta builds up just like plaque in your arteries or on your teeth. This plaque in your brain is a hallmark of Alzheimer’s disease. When amyloid beta builds up beyond a certain point, it becomes toxic to nerve cells, destroys synapses (the connections between nerve cells)...
If this new hypothesis of Alzheimer’s is borne out, the good news is that it could lead to effective treatments for the condition. Although there is plenty you can do to reduce your risk of gum disease, Cortexyme is hoping it can stop or even reverse Alzheimer’s using molecules...
of the disease and neuronal loss also reduce seizure activity?” requires a model that has seizures. However, research aimed at addressing the root cause of the disease, such as gene therapy approaches to replaceNPC1expression or strategies to clear cholesterol from cells by bypassing NPC1-...
which releases soluble APPα which precludes generation of Aβ. The net result is to enhance the production of the putatively neurotoxic Aβ42monomer at the expense of the putatively neuroprotective Aβ40. The current version of the amyloid hypothesis claims that Aβ42accumulation into soluble olig...
In contrast, cytosolic release of the mitochondrial protein cytochrome c may play a regulatory role by competing with NLRP3 for binding to cardiolipin [46]. A reduction in cardiolipin synthesis was shown to reduce NLRP3 inflammasome activation [41]. Comparatively, the requirement for both MAVS and...
A reduction in cardiolipin synthesis was shown to reduce NLRP3 inflammasome activation [41]. Comparatively, the requirement for both MAVS and mitofusin-2 was specific to NLRP3 activation by RNA viruses [42, 43]. This localization to MAVS is dependent on the N-terminus of NLRP3 and is ...
Amyloid plaque and NFT staining images were adapted from Winblad et al. (2016). 1.1.1. Amyloid/Aβ Models The critical role of Aβ in AD led to the development of Tg mice carrying FAD mutations (FAD-Tg) that increase the proteolytic processing of APP to Aβ42 or increase the Aβ42...
That curiosity led a 17-year-old Fuller to move to the US, where he attended Livingstone College in North Carolina. He went on to study medicine at Long Island College Hospital in Brooklyn and earn a medical de