The configurational analysis of complex natural products by NMR spectroscopy is still a challenging task. The assignment of the relative configuration is usually carried out by analysis of interproton distances from NOESY or ROESY spectra (qualitative or quantitative) and scalar (J) couplings. About ...
In this co-conformational state, it seems that the DB24C8 tends to interact with the more acidic hydrogen atoms H13, while hindrance due to the rotations of the next amide and N-C16 bonds hampers this interaction. The ROESY 1H NMR spectrum of 3-Boc presented in Figure 5a supports this ...
von Osten [36] who was once thought to be able to do arithmetic but turned out to carefully read his master's and his audience's response to arithmetic questions is an excellent case that continues to be relevant today [37]. It is quite disturbing that Tuyttens et al. [38] recently ...