idiopathic neutropeniaNeutropenias (NPs), being acute and often transient, or chronic, range from life-threatening conditions with very low absolute neutrophil blood counts (ANC) to disorders characterized by only mild NP and of no obvious significance for health. Many are caused by genetic ...
We generally use the minimum dose and frequency to maintain a neutrophil count in a range to prevent symptoms. This can usually be accomplished by maintaining an ANC >250 to 300 and can often be maintained with dosing one to three times weekly. Although there is some concern that chronic G...
Identification of patients at high risk of severe bleeding will help start the treatment timely to prevent fatal hemorrhage, even in those with higher platelet counts, whereas this remains a big challenge. Older age, low platelet counts, the presence of comorbidities, and concurrent anticoagulants ...
and always needs to be tailored to the patients and disease phases. In this review, we address the concepts of adult ITP diagnosis and management and provide a comprehensive overview
Alternatively, there are ongoing clinical trials for patients who test positive for MRD, with the aim to reinduce molecular CR and prevent hematologic relapse. The therapeutic approaches include unselected or targeted therapies (eg, hypomethylating agents [HMAs], intensive chemotherapy, venetoclax, or...
Consider side effects and how to deal with them.Talk to your doctor about possible side effects and if there are ways to prevent or treat them. You might not be able to avoid certain side effects, but you can make a plan for them. For example, if chemotherapy will cause hair loss, yo...
The human immune system is an important set of organs and processes that all work together to protect the body from invasion by foreign pathogens, like bacteria. Some of the components of the immune system include the white blood cells, the spleen, and the bone marrow....
Nurses who work in HSCT units have a key role in treatment management and require specific training to: Understand, prevent and manage the early and late effects of HSCT. Care for high-risk patients. Inform and educate patients and their caregivers. ...
congenital,neutropeniaComment on Rosenberg et al, page [4628][1] In this issue of Blood , an updated analysis of the Severe Chronic Neutropenia International Registry dataset by Rosenberg and colleagues reports an alarming incidence of evolution to MDS/AML in patients who are treated with ...
To ensure the effect of ICIs, anti-PD-1 antibodies must be able to stay on the target points on the surface of T cells to prevent T cell failure. However, TAM can "rob" anti-PD-1 anti- bodies from the surface of CD8+ positive T cells, swal- low them into the body, and make ...