Visualization of the virus’ spike protein (cyan) surrounded by mucus molecules (red) and calcium ions (yellow). The viral membrane is shown in purple. Credit: UC San Diego’s Lorenzo Casalino, the Amaro Lab, and the research team. UC San Diego develops computer model to aid understanding ...
The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is a candidate vaccine antigen that binds angiotensin-converting enzyme 2(ACE2), leading to virus entry. Here, it is shown that rapid conversion of recombinant RBD into particulate form via admixing with liposomes containing ...
If we had to simplify diet imperatives to a point, it would be to eat in a way that keeps your blood sugar stable throughout the day, meaning no naked carb loading (“naked” carbs are those consumed without fat or protein that mitigate the blood sugar spike), highly processed foods, o...
Many microbes appeared equipped to protect themselves against colibactin. Balskus’s lab identified a resistance gene encoding a protein that neutralizes the compound in a wide variety of bacteria. Though colibactin clearly has a dangerous side, it may serve as more than just a lethal...
Researchers discovered a new antibody (light blue) that neutralizes the COVID-19 virus, by binding to the virus’s spike protein (grey) and locking it in a closed conformation. Credit: Christopher Barnes, California Institute of Technology ...
To answer this question, we need to understand a bit about how immunity to SARS-CoV-2 (thevirusthat causes COVID) works. After being infected or vaccinated, theimmune systemdevelops specific antibodies that can neutralize SARS-CoV-2. B cells remember the virus for a period of time. In add...
Bamlanivimab is a neutralizing IgG1 monoclonal antibody (mAb) directed against the spike protein of SARS-CoV-2. It is designed to block viral attachment and entry into human cells, which should neutralize the virus, and potentially prevent and treat COVID-19. ...
the world. The viral spike protein (S) significantly contributes to host cell entry, and mutations associated with it, particularly in the receptor-binding protein (RBD), either facilitate the escape of virus from neutralizing antibodies or enhance its transmission by increasing the affinity for ...
Current COVID-19 vaccines are based on the SARS-CoV-2 spike protein, which the virus uses to bind to and infect host cells, of the original Wuhan-hu-1. But the emerging “variants of concern”—deemed so because they appear to be more transmissible or deadlier than the wild-type SARS-...
Antibodies, small proteins produced by the immune system, can attach to specific parts of avirusto neutralize it. As scientists continue to battleSARS-CoV-2, thevirus that causesCOVID-19, one possible weapon is a synthetic antibody that binds with the virus’ spike pro...