Genetic Diseases, InbornLinkage DisequilibriumPolymorphism, GeneticGenetics, MedicalModels, GeneticNat Genet. 2000 Oct;26(2):151-7. Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Reviewdoi:10.1038/79866Weiss, Kenneth M....
The head-to-toe suits that the researchers don in an airlock each morning ensure that no stray flake of skin or bead of sweat contaminates the bones with modern DNA. Each night the entire lab is bathed in gene-destroying ultraviolet light. The clean lab feels as if it belongs ...
③“That becomes an interesting strategy for potentially improving DNA repair as a way to treat the disease, something that has not yet been widely pursued.” (“How a Breast Cancer Gene May Affect Alzheimer’s” By Al...
What Is a Gene Gun? The gene gun is a device used to transfect cells with foreign DNA by bombarding the target cells with DNA-coated microparticles. It was originally developed using plant tissue as the target but can also be used with yeast, bacteria, mammalian cell lines, and insects. ...
Lessons from human arteries: how to design a gene therapy strategy for treatment of cardiovascular disease. Morishita R (1998) Lessons from human arteries: how to design a gene therapy strategy for human treatment of cardiovascular disease. Circ Res 82:1349–1351. : 10.1161/01.RES...
The researchers captured gene expression data from each cell of the embryo, one cell at a time. The teams collectively profiled more than 200,000 cells at multiple time points over 24 hours for both species. To map the lineage of essentially every cell as an embryo develops, along with the...
elegans: a genetic model for the study of RNA–protein condensates. J. Mol. Biol. 430, 4702–4710 (2018). Article CAS PubMed PubMed Central Google Scholar Boswell, R. E. & Mahowald, A. P. Tudor, a gene required for assembly of the germ plasm in Drosophila melanogaster. Cell 43, ...
The approach provides a useful quantitative and testable framework for assessing the interplay between gene actions or interactions and developmental changes. 展开 关键词: Animals Humans Mice Chromosome Mapping Embryonic Development Quantitative Trait Loci Gene Expression Regulation, Developmental ...
3 how to clone a gene 3Howtocloneagene •3.1WhatisCloning•3.2OverviewoftheProcedures•3.3GeneLibraries•3.4Hybridization•3.5PolymeraseChainReaction(PCR)3.1Whatiscloning 3.1whatiscloning Cloningmeansusingasexualreproductiontoobtainorganismsthataregeneticallyidenticaltooneanother,andtothe`...
PI3K inhibition activates SGK1 via a feedback loop to promote chromatin-based regulation of ER-dependent gene expression. Cell Rep. 27, 294–306.e5 (2019). Article CAS PubMed PubMed Central Google Scholar Toska, E. et al. PI3K pathway regulates ER-dependent transcription in breast cancer ...