Stroke is one of the most severe complications to affect children with sickle cell anaemia (SCA). Transcranial doppler (TCD) is an accurate and non-invasive method to determine stroke risk. Randomised controlled trials have demonstrated the efficacy of chronic transfusion therapy in stroke prevention...
Blood transfusion remains an important therapeutic intervention in patients with sickle cell disease (SCD), aiming to both increase the oxygen carrying capacity of blood and to reduce the complications of vaso-occlusion. Simple, manual exchange and automated exchange can be effective in reducing the ...
Sickle cell disease (SCD) is a common hereditary disease in Iran. In developed countries, newborn screening programs have been established to ensure early diagnosis, but in most developing countries, screening is not performed and the diagnosis is often delayed. The aim of the present work was ...
The dominant or recessive mutated genes may become incapable to produce a specific enzyme or result in an inborn error of metabolism. Some common examples of genetic diseases are cystic fibrosis, Alzheimer's, albinism, and sickle cell disease....
As a single mother of three young daughters diagnosed with sickle cell disease, Mapillar’s life is busier than most. In addition to helping with homework, attending after-school activities and scheduling play dates, Mapillar also has to make time for regular doctor’s visits and organizing rec...
Sickle cell disease (SCD) is a family of inherited red blood cell disorders that occur when hemoglobin—the protein in red blood cells that carries oxygen throughout your body—takes on a C, or sickled, shape, instead of a healthy oval shape. Cells become hard and sticky, blocking blood ...
Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease. Children with sickle cell disease (SCD) and strokes receive blood transfusion therapy for secondary stroke prevention; despite this, approximately 20% expe... ML Hulbert,RC...
Research into sickle cell disease is personal, Hyacinth said, as his nephew has SCD and he and his son both havesickle cell trait. People with sickle cell trait inherit one sickle cell gene from a parent and typically do not have symptoms of SCD, but they can pass the trait on to their...
All those surveyed agreed that a dedicated transition programme would be useful to their health needs, and would assist in transferring care [n = 5], providing support [n = 4], and providing an opportunity to meet other adults with sickle cell disease [n = 2]. Participants varied in self...
Pediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of diseases of children and disorders of development, extending from molecular biology to epidemiology. Use of model organisms and in vitro techniques relevant to developmental biology and medicine are ...