We investigated patients with a history of systemic anaphylatic reactions to honeybee or wasp stings. Nine (75%) of 12 patients with raised tryptase concentrations but only 28 (28%) of 102 patients with lower tryptase concentrations, had a history of severe sting reactions......
In a) cytotoxic cells (defined as GZMA+, NKG7+, CD94+), whose mRNAs resulted increased by Imatinib; in b) NK cells (CD56 bright), that increased after Imatinib treatment; in c) mast cells (defined as CPA3+, tryptase+, MSGA2+, CCL22+), whose RNAs were decreased by Imatinib; in ...
can ensure a correct diagnosis of anaphylaxis. The in vitro diagnosis of anaphylaxis includes serial measurement of the mediators released during an anaphylactic reaction, namely, tryptase, histamine, chymase, carboxypeptidase A3, platelet-activating factor, and other products from mastocytes. Measurement ...
ESOPHAGEAL motility disordersTRYPTASESMOOTH muscleESOPHAGEAL achalasiaGLIAL cell line-derived neurotrophic factorThis article discusses the changes in esophageal smooth muscle in patients with achalasia, a primary esophageal motor disorder characterized by impaired lower esophageal sphincter relaxation and...
in vitro model; transcriptome; mRNA; mast cell; tryptase; chymase; serine protease; FcεRI; heparin; histamine1. Introduction Mast cells (MCs) are tissue-resident cells that are known primarily for their prominent role in IgE-mediated allergies [1,2]. They are evolutionary old and MCs or ...
These cells also contain tryptase–heparin complexes [20]. For a general overview of an evolutionary perspective on MCs, please see Ref. [21]. Interestingly, test cells are responsive to c48/80, the prototypical agonist of the MC-selective receptor Mas-related G-protein-coupled receptor X2 ...