The TCR integrates forces in its triggering process upon interaction with pMHC. Force elicits TCR catch-slip bonds with strong pMHCs but slip-only bonds with weak pMHCs. We develop two models and apply them to analyze 55 datasets, demonstrating the models’ ability to quantitatively integrate and...
Further, the present study would pave way to design new experiments on TG-bound CETP complexes. Materials and Methods The coordinate file of CETP with PDB ID 2OBD was downloaded from the RCSB Protein Data Bank19. Four N-terminal missing residues, 1A-S-K-G4 were incorporated using Modeller ...
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The configuration of the Myo6 active state, the nature of its Lever arm and its oligomeric state can make critical differences in the way the force produced by the motor is used16,30,31. In fact, Myo6 is well adapted to transport as well as to anchor, depending on the load it is wo...