The TCR integrates forces in its triggering process upon interaction with pMHC. Force elicits TCR catch-slip bonds with strong pMHCs but slip-only bonds with weak pMHCs. We develop two models and apply them to analyze 55 datasets, demonstrating the models’ ability to quantitatively integrate and...
NTRK fusions represent a rare molecular alteration in breast cancer. Ross et al. identified only 16 tumors (0.13%) with NTRK gene fusions among 12,214 locally aggressive, relapsed, or metastatic BC using comprehensive genomic profiling. Among them, nine cases were ductal carcinomas and three we...
Ovarian cancer is one of the leading causes of cancer-related death among women. Resistance to the disease occurs in more than 70% of the cases even after treated with chemotherapy agents such as paclitaxel- and platinum-based agents. The immune system is increasingly becoming a target for inte...
Cholesterol in the circulation originates from either the diet or endogenous synthesis in cells. To ameliorate abnormalities, drugs have been developed to inhibit cholesterol pathways. A meta-analysis showed that with pharmacological treatment that is initiated later in life, all-cause mortality was ...
localisation. The aberrant migration in gel and nuclear localisation are not related to each other. Hiding the N-terminus with an epitope tag strongly affected its mobility in gel and expression in cells. Our results suggest that the intrinsically disordered domains flanking the MHD determine the ...
Particularly in Costa Rica, Ecuador, and Peru, this fun alteration of the word bueno means you're saying a particular object is really cool. Typically it isn't used to describe people.[13] For example, you might say "Ese coche es buenazo" or "That car is cool." While you may hear...
5. Role of Adult Stem Cells and Modulated Cell-Cell Communication in the Multi-Stage, Multi-Mechanism Process of Carcinogenesis To link stem cells and cell-cell communication with the mechanisms of mutagenesis and epigenetic alteration of gene expression, cancer can be taken as a case study. In...
However, here the alteration pattern of the TUCP with the desalination flow ratio is the same for all three investigated humidifier effectiveness levels. SustSauinstaabinilaitbyili2t0y2210,2113,,1735, 771571 252o5f o40f 40 2.6 εHum=1 2.2 εHum=0.85 εHum=0.7 1.8 1.4 1 1 1.5 2 2.5 3...