How to establish efficient pluripotent stem cellsThe present invention provides a method for improving the efficiency of establishing induced pluripotent stem cells, the method including inhibiting the functioning of STAT1 in a nuclear reprogramming process of a somatic cell.山中 伸弥...
SOMATIC cellsLIFTING & carrying (Human mechanics)Background: Human induced pluripotent stem cell (iPSC)-derived peripheral sensory neurons present a valuable tool to model human diseases and are a source for applications in drug discovery and regenerative medicine. Clinically, perip...
Discuss strategies and methodologies to develop scalable, robust, and cost-effective manufacturing processes for allogeneic cell therapies Showcase how induced pluripotent stem cells (iPSC) are being used as renewable sources of allogeneic cancer therapies Demonstrate the criticality of GMP manufacturing capa...
To understand this concept, we need to delve into the world of cellular biology and the groundbreaking work of Shinya Yamanaka, who won the Nobel Prize for his discovery of induced pluripotent stem cells (iPSCs). Yamanaka identified four genes, now known as the Yamanaka fa...
PLURIPOTENT stem cellsMOLECULAR clockSOMATIC cellsCIRCADIAN rhythmsThe circadian rhythm is necessary for the homeostasis and health of living organisms. Molecular clocks interconnected by transcription/translation feedback loops exist in most cells of the body. A puzzling exemption to ...
All blood cells (RBCs, WBCs and platelets) come from the same type of cell, called the pluripotential hematopoietic stem cell. This group of cells has the potential to form any of the different types of blood cells and also to reproduce itself. This cell then forms committed stem cells ...
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier experiments have found that VSMCs possess high plasticity. Vascular injury stimulates VSMCs to switch into a dedifferentiated type, also known as synthetic VSMCs, with a
All blood cells (RBCs, WBCs and platelets) come from the same type of cell, called the pluripotential hematopoietic stem cell. This group of cells has the potential to form any of the different types of blood cells and also to reproduce itself. This cell then forms committed stem cells ...
The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature 2006, 439, 470–474. [Google Scholar] [CrossRef] Zeng, X.; Hou, S.X. Enteroendocrine cells are generated from stem cells through a distinct progenitor in the adult Drosophila posterior midgut. Development 2015...
relies on a Nobel Prize–winning discovery, called reprogramming, that allows scientists to induce any cell to become “pluripotent”—capable of forming any other type of tissue. The next step: cajole those induced stem cells to become eggs whose genetic makeup would match that of the patien...