Luckily, we have been faced with a "trial run" in August of 2006 when a new test became available to detect large rearrangements in the BRCA1 and BRCA2 genes. These types of mutations would not have been detected by the sequencing test which was the only assay available prior to that ...
To those wondering, can I get life insurance if I had breast cancer? If you are in remission, have a very slow-moving stage of breast cancer, and have no other medical issues, you should be able to be approved for term life insurance at the Standard level like Nancy. While this might...
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Far fewer headlines covered the fact that around 40% of changes to the BRCA1 and BRCA2 genes are a black box. Are these gene variants harmful, harmless, or somewhere in between? Scientists don't fully know—and that carries consequences. "The evidence is that people with variants of uncert...
lupus: nonrandom XCI, incomplete silencing of certain genes on the Xi, and the potential for the XIST ribonucleoprotein complex to activate the immune system. By investigating these mechanisms, researchers aim to better understand how variations in XCI mechanisms contribute to the development of ...
PIK3CA is one of the most frequently mutated genes in cancer; the PI3K pathway is altered in a large number of cancer types, driving cell signalling, growth and metabolism, and PI3K inhibitors have been in development for over four decades. Seven drugs that target the PI3K pathway have receive...
Advanced prostate cancer remains one of the most common and deadly cancers, despite advances in treatment options. Immunotherapy has provided little benefit to a majority of patients, largely due to the immunosuppressive tumor microenvironment that gives
Prevent disease.Once you know you carry a certain gene, you may be able to make lifestyle changes or get medical treatment so you don’t get sick. For example, women who carry the BRCA1 or BRCA2 gene mutation are at higher risk forbreast cancer. To lower their risk, they may choose...
Participants’ interpretations of genetic test results were found to vary widely. While this variation often aligned with variation in interpretations by cancer genetics services, participants also had difficulties with the complexity and recall of genetic test results. Participants had a range of psycholo...
The fathers and husbands of Hispanic families are more likely to stop their children from going to the doctor until the very last minute and are more likely themselves to not do anything until they get so sick they must go to the M., Feinglass, J., & Simon, M. A. (2013). Pregnancy...