How Senescent Cells Spur Aging and CancerDavid Stipp
The SASP of senescent cells can be beneficial or detrimental to the organism. On one hand, the pivotal function of the SASP of acute senescent cells is to recruit different immune cells including natural killer (NK) cells, T cells, and macrophages, which in turn eliminate those senescent ...
Omega-3-Rich Foods- Let's get one thing out of the way. Omega-6 fatty acids are not bad. We need those, too. What is bad in the contemporary approach to nutrition peddling hyper-produced, convenient semblances of food is the ratio of these fatty acids. Ideally, you'd have a 1:1 ...
Senolyticsthat decrease the number of senescent cells in the body, referred to as “zombie cells” — neither alive or dead they nonetheless secrete harmful chemicals that age you. NAD+ precursors, such as NMN and NR, that research shows activate a family of proteins called sirtuins, our longe...
To keep our bodies running smoothly, our cells are constantly churning out proteins using the blueprints found in DNA. These proteins are the very fabric of life and, among other things, make up the enzymes that digest our food, create energy and other life-sustaining processes. Damage a cruc...
The three calmosulin genes are associated with different functions according to the state of the cell. Some authors investigated the difference in the role of calmodulin between GBM senescent cells and stem cells and they noticed that CALM1 is expressed significantly in stem cells while CALM2 is ...
of cells known as osteoclasts. When the balance between the actions of the two is off-kilter, the result is too little (or too much) bone. This happens, for example, inosteoporosis, a common condition of weak and brittle bones that results when bone synthesis fails to keep up with ...
From an official standpoint, there’s not much that can be done to get rid of senescent cells. Once they’re there, they’re not going anywhere – or so goes the claim. The truth of the matter is that there are many ways to help combat cellular senescence that work to give the body...
Cells that permanently stop dividing have long been recognized as one of the body's defenses against cancer. Now they are also seen as a sometime culprit in cancer and a cause of aging
Cinelli et al., "How to utilize Ca2+ signals to rejuvenate the repairative phenotype of senescent endothelial progenitor cells in elderly patients affected by cardiovascular diseases: a useful therapeutic support of surgical approach?" BMC Surgery, vol. 13, p. S46, 2013....