All Rights Reserved 1 0 HOW TO GET IDEAS idea, better yet, a succession of ideas, by ourselves? Yes, there is a way, and I don't mean inspiration which some people would like to meet by appointment in a lunch room. Developing an idea is much like developing an invention. Sir Joshua...
But don’t just expect to find it in the obvious places. Reggae’s influence is felt (often literally, thanks to heavy bass) wherever rock and pop are played. It echoes in mainstream British pop; it loaned its culture to hip-hop. It’s considered “cool” by people with no connection ...
Major changes have taken place within the last few years in the management of follicular lymphoma (FL) leading to substantial improvement in prognosis and overall survival. For some patients with limited disease stages I and II, radiotherapy may be assoc
Molecular imaging is one of the pillars of precision surgery. Its applications range from early diagnostics to therapy planning, execution, and the accurate assessment of outcomes. In particular, molecular imaging solutions are in high demand in minimally invasive surgical strategies, such as the subst...
Figure 4. ROS-dependent mechanism of partial elimination of IRS-1 and IGF-1 resistance, contributing to the increased expression of E3-ubiquitin ligases [65,66]. During the first days of unloading (according to [16], during the first 24 h) under the action of mitochondr...
I get a lot of pushback when I suggest new writers should write short stories. Everyone wants to write a book. (Okay, maybe not everyone, but if you ask a hundred people if they’d like to write one, I’d bet seventy-something of them would say yes.)Anthologiesand short story colle...
In this scenario, the target Mac must be able to boot from USB for the USB thumb drive to work. Apple's original resource fork editor - ResEdit. Using the bless command Going all the way back to early versions of Mac OS, Apple included certain special settings on the System Folder and...
Knocking out the IL18R resulted initially in partial resolution of symptoms including skin and visceral disease in young mice and a normalization of serum cytokines in comparison with the IL-1R knock-out mice. However, aging of the IL-18R knock-out mice led to increased systemic inflammation ...
Regardless whether aiming for complete or partial IS withdrawal, one should carefully consider the variable effect of concomitantly applied drugs on Treg in vivo survival, ex- pansion, and function. From studies in animal models, we know that a high dose of CNIs hampers Treg proliferation, ...
It would be already a success to achieve at a relatively early time point a low dose CNI monotherapy, thereby minimizing the side effects but avoiding unnoticed inflammatory processes due to e.g., bystander activation of cross-reactive T cells. Regardless whether aiming for complete or partial ...