GermlineTP53PVs show variable penetrance, related to the variant’s effect on the tumor suppressor activity of the protein. Most disease-causing variants are missense, and those with a dominant-negative effect (DNE) result in malfunctioning or non-functioning p53 tetramers, which results in reduced...
Apoptosis has been established as a mechanism of anti-cancer defense. Members of the BCL-2 family are critical mediators of apoptotic cell death in health and disease, often found to be deregulated in cancer and believed to lead to the survival of malign
In this regard, it is important to understand how intracellular signaling pathways receive information about the reduction/termination of contractile activity and, based on this information, rearrange their work, i.e., what metabolic, ionic and mechanobiological events (directly cau...
In recent years, the RNA molecule became one of the most promising targets for therapeutic intervention. Currently, a large number of RNA-based therapeutics are being investigated both at the basic research level and in late-stage clinical trials. Some o
Positive regulation of the NLRP3 inflammasome is mediated by phosphatase and tensin homolog (PTEN), a well-known tumor suppressor. PTEN directly interacts with NLRP3 and mediates dephosphorylation of Y32 in the PYD, enabling the NLRP3–ASC interaction and inflammasome maturation. It has been ...
Over the past decade, cancer diagnosis has expanded to include liquid biopsies in addition to tissue biopsies. Liquid biopsies can result in earlier and more accurate diagnosis and more effective monitoring of disease progression than tissue biopsies as
Many tumours have mutations either of p53 itself or of members of its signalling pathway underlining its importance as a tumour suppressor [4]. To prevent inappropriate induction of senescence or cell death, the p53 level in the cell is tightly controlled through its activating pathways. These ...
Apoptosis has been established as a mechanism of anti-cancer defense. Members of the BCL-2 family are critical mediators of apoptotic cell death in health and disease, often found to be deregulated in cancer and believed to lead to the survival of malign
Yuan K, Jin X, Mo X et al (2024) Novel diagnostic biomarkers of oxidative stress, ferroptosis, immune infiltration characteristics and experimental validation in ischemic stroke. Aging 16(1):746–761 Liu Y, Dong J, Zhang Z et al (2023) Regulatory T cells: a suppressor arm in post-stroke...
The promise of personalized medicine is that each patient’s treatment can be optimally tailored to their disease. In turn, their disease, as well as