In this regard, it is important to understand how intracellular signaling pathways receive information about the reduction/termination of contractile activity and, based on this information, rearrange their work, i.e., what metabolic, ionic and mechanobiological events (directly cau...
GermlineTP53PVs show variable penetrance, related to the variant’s effect on the tumor suppressor activity of the protein. Most disease-causing variants are missense, and those with a dominant-negative effect (DNE) result in malfunctioning or non-functioning p53 tetramers, which results in reduced...
In recent years, the RNA molecule became one of the most promising targets for therapeutic intervention. Currently, a large number of RNA-based therapeutics are being investigated both at the basic research level and in late-stage clinical trials. Some o
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Job facets were “work in general”, “work with your colleagues”, “relation with supervisor “, “team climate in your division”, and “work conditions at your workplace”. Response format was a 5-point Likert scale, ranging from not satisfied at all [1] to very satisfied [5]. ...
A detailed literature search has been conducted on PubMed for collecting information pertaining to the COVID-19; the history, origin, key structural features, and mechanism of infection of SARS-CoV-2; the repurposed drugs in use for the management of COVID-19, and the anti-inflammatory role...
The identification of radicals (anionic or cationic) constituent element of a mixture, is generally performed through qualitative analysis. In this method, the properties of constituent ions are tested by some suitable reagents.Answer and Explanation: ...
The promise of personalized medicine is that each patient’s treatment can be optimally tailored to their disease. In turn, their disease, as well as
skin, the consequences to skin-related biological processes and, based on such knowledge, we suggest some therapeutic targets. We also explored the recent advances regarding the molecular clock disruption in melanoma, its impact on the carcinogenic process, and its therapeutic value in melanoma ...
Zebrafish U8 mutants were found to exhibit defective rRNA biogenesis and activation of the tumor suppressor p53 (tp53), which monitors ribosome biogenesis dysfunction in a regulatory loop known as “nucleolar stress surveillance.”11, 12, 13 Functional assessment of LCC disease-associated U8 alleles ...