What Mitch said is correct, the phenyl group will stabilize the charge if you form an enolate to the left side of the carbonyl (as you have it drawn). Phenyl groups are essential neutral in terms of withdrawing/donating ability, that is to say they can stabilize a positive or negative ch...
Briefly explain enolate formation. Describe the process of electroplating. How do you manufacture ammonia? What is the definition of a eutectic mixture? The product is essentially pure SnI_4, with no SnI_2 being formed. Explain why this happens. ...
Step 2: Preparation of SN-38 and Conversion to Coupling Intermediate The conversion of azabicycle 312 to SN-38 is described in steps. The pyridone nitrogen within 312 underwent Michael addition to t-butyl acrylate (313) under mildly basic conditions, and the resulting enolate reacted with the ...
Briefly explain enolate formation. What distinguishes transfer hydrogenation from a "normal" (not-transfer) hydrogenation? Explain your answer. How to carry out qualitative analysis on (NH_4)_2SO_4.FeSO_4.6H_2O? How does acid rain form?
Various methodologies published in the literature dealing withα-amino carboxylic acid asymmetric synthesis are presented in a digest form. In each cas
Dependence of the Reactivities of Titanium Enolates on How They Are Generated: Diastereoselective Coupling of Phenylacetic Acid Esters Using Titanium TetrachlorideLooks at the achievement of oxidative coupling of phenylacetic acid esters, with the treatment of the esters with TiCl4 and adding Et3N to ...
19Reactions of Aromatic Molecules 20Aldehydes and Ketones 21Carboxylic Acid Derivatives 22Enols and Enolates 23Amines 24Carbohydrates 25Fun and Miscellaneous 26Organic Chemistry Tips and Tricks 27Case Studies of Successful O-Chem Students Comments Comment section...
In the Path-endo, the initial intermolecular nucleophilic addition of 5 to the benzyl position on 2a via transition state 6-ts generates enolate complex 7 with a free energy barrier of 8.0 kcal·mol−1. The subsequent intramolecular cyclization leads to the formation of intermediate 9, ...
4. Bottom Line: Use Relative Electronegativities, Not Formal Charges, To Determine Electron Densities Bottom line:if H3O(+) is reacting with an electron rich species, those electrons will go to thehydrogens(since they are electron poor),NOTthe oxygen!!
The carbonyl group refers to a carbon double-bound to an oxygen atom. The carbonyl group is capable of resonance where the pi bond collapses up towards the oxygen. The charged resonance form is not very stable due to an incomplete octet on carbon, as well as the separation of charge betwee...