Biological analyses show that an unexpectedly high number of the conserved sequences correspond to functional cis-regulatory regions that influence gene transcription. Because research biologists are often unfamiliar with the bioinformatic resources at their disposal, this commentary discusses how to integrate...
The evolu- tionary implications and the presence of coding regions in some TEs can confuse gene annotation, and also hinder the process of genome assembly, making particularly crucial to be able to annotate and classify them correctly in genome sequences. This review is intended to provide an ...
and sized by comparison to an internal standard. While DNA sequencing by CE is used to determine the specific base sequence of a particular fragment or gene segment, this technique can also provide sizing, relative quantitation, and genotyping information for fluoresce...
We find that many species-specific gene groups are enriched for the same flanking regulatory sequences as those found in the orthologous gene groups from S. cerevisiae, indicating that those regulatory systems have been conserved in multiple ascomycete species. In addition to these clear cases of ...
How the sequence of a gene can tune its translation. Cell. 2010; 141 :227–229. [ PMC free article ] [ PubMed ]Fredrick K, Ibba M. (2010). How the sequence of a gene can tune its translation. Cell 141: 227-9.Fredrick K, Ibba M. How the sequence of a gene can tune its ...
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The Gene Expression Omnibus (GEO) is a data repository hosted by the National Center for Biotechnology Information (NCBI). NCBI contains all publicly available nucleotide and protein sequences. Presently, all records in GenBank NCBI are generated from direct submission to the DNA sequence databases ...
After sample preparation and on-machine sequencing, high-throughput gene sequencing will generate huge gene sequence data and involve massive data storage, calculation and transmission, which has extremely high requirements on the underlying infrastructure . The original IDC computer room has been unable ...
Perspectives: sequence data base searching in the era of large-scale genomic sequencing. Genome Res. 6, 653–660 (1996). Article CAS Google Scholar Download references Rights and permissions Reprints and permissions About this article Cite this article Question 1 How does one find a gene of ...
RNA molecules can fold into intricate shapes that can provide an additional layer of control of gene expression beyond that of their sequence. In this Review, we discuss the current mechanistic understanding of structures in 5′ untranslated regions (UTRs) of eukaryotic mRNAs and the emerging metho...