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If a liquid has poor solubility and requires a reduced mixing speed, ramping up the number of mixing cycles can help to maintain accuracy. Even aqueous solutions change their characteristics with different analytes, and may not mix rapidly, forcing you to slow ...
The liquid/amorphous form of a drug has higher free energy than the crystalline form, hence a tendency for crystallization. “Brick dust molecules” are drugs with very low aqueous solubility and are difficult to formulate for instance as...
Magnetic bead platforms streamline bench-scale purifications by allowing beads to be easily mixed with the sample in a tube and rapidly separated using a magnetic tube rack. This significantly reduces processing time, as the mobile phase can be quickly decanted or pipetted out directly. In contras...
Segregation of Zn and Cu is shown at the oxide/metal interface with Zn up to 28 at.% and Cu up to 6 at.%, which is far beyond the solubility limit of Zn (0.85 at.%) and Cu (0.02 at.%)26 in Al at room temperature. We note that the field change at the oxide/...
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Eur. monograph that will be applicable to all current and future manufacturers of the drug substance or drug product. The differences between the two processes and their applicability are illustrated in Figure 1. Figure 1. Difference between multi-source and single source products for European ...
To elucidate its pH-responsive mechanism, FTIR analysis revealed that the stretching vibration of the imine bond at 1610 cm−1 significantly decreased when the pH dropped from 7.4 to 5.6, and a peak appeared at 1704 cm−1, indicating bond cleavage (Figure 2B). To verify the targeting ...
How Temperature Affects The Solubility Of Salt Crystals Intermolecular forces hold molecules together when they are in solid or liquid state. However, water has the ability to dissociate many salts and ionic compounds. This is called dissolving. When NaCl is added to water, it dissociates into th...
Factors That Affect Solubility Dilutions When making a solution, it's handy to know if one thing will dissolve in another. After all, if somebody wants you to make them a liquid solution of one chemical, it won't make you look good if you bring them a beaker of liquid with sludge sit...