Mutation rate is an essential parameter in genetic research. Counting the number of mutant individuals provides information for a direct estimate of mutation rate. However, mutant individuals in the same family can share the same mutations due to premeiotic mutation events, so that the number of ...
obtaining a reliable estimate of mutation rate is the most important consideration; unless this is accomplished, estimates can be biased by orders of magnitude.4At least some estimators of contemporary Ne appear to be robust to relatively high (approximately 10%) equilibrium levels of migration, so...
This transition probability depends on the mutation rate and mutation bias, in addition to nucleotide composition. We estimate these parameters primarily from the data on the yeast, Saccharomyces cerevisiae (Table 1)17. Our choice is motivated by the fact that the budding yeast is a convenient ...
Some years ago, Townsend and his colleagues devised a way to estimate how important each mutation is to a cancer by looking at the frequency of each individual mutation in a large number of tumors as well as the underlying rate at which that mutation appears. "It was a breakthrough, becaus...
Recently, a first direct estimate of the single base-pair substitution rate in the human germline was derived from genome-wide DNA sequence data. This result has shed new light upon the question of whether cutting-edge molecular genetic analysis could, in a paternity dispute, potentiate discriminat...
This similarity has been taken as an indication of multiple domestications and the frequency of the rarest alleles has been used to estimate that about 100 tough-rachis different mutants were necessary for the inclusion of the allozyme diversity of the wild barley in the domesticated crop. ...
How to estimate gene flow? How does gene flow restore alleles? How are genetic drift and gene flow different? How does gene flow cause microevolution? What are the main mechanisms that affect gene pools? How do polygenic traits affect selective breeding? How does cloning affect the gene pool?
Once it’s an adult, your Scottish Fold will have plenty of toys and very few doctor visits, so it’s not too costly and you may even be able to maintain your Fold with less than our minimum estimate. Additional Costs to Factor In If you like to take long vacations, we recommend ...
The data used in building the phylogenetic tree can also be used to estimate the mutation rate of the Zika virus, which appears to vary between about 12 to 25 mutations per year, equivalent to 0.12%-0.25% of the RNA mutating each year. This rate is very high when compared to the human...
Here we applied a generation time of 12 years (Rogers and Kidd, 1996) and the specific mutation rate of primate HVRI of 15–20% per million years (Jensen-Seaman and Kidd, 2001). To estimate divergence times between clades, we concatenated the Brown Region, cyt b, and HVRI sequences (...