Barriot R, Sherman DJ, Dutour I (2007) How to decide which are the most pertinent overlyrepresented features during gene set enrichment analysis . BMC Bioinformatics 8 : 332.R. Barriot, D. J. Sherman, and I. Dutour, “How to decide which are the most pertinent overly-represented ...
Single-cell analysis reveals regulatory gene expression dynamics leading to lineage commitment in early T cell development. Cell Syst. 9, 321–337 e9 (2019). This study focuses on patterns of transcription factor expression in the earliest stages of T cell differentiation and their relationship to ...
age-matched crocidolite-exposed, and age-matched crocidolite-exposed with observable tumors. Among those groups we performed differential expression analysis between crocidolite-exposed and sham, and detected 5976 differentially
Until recently, the extensive diversity of the gut microbiome and its myriad biochemical processes have defied comprehensive analysis. Novel high-throughput techniques are beginning to unravel the complexities of the intestinal compartment—and are illuminating how many unknown variables are left to ...
gene expression. The SNP-gene associations are tissue specific; hence we can estimate what genes are more highly associated with a disease at the tissue level. Part 2 conducts eMAGMA gene-set analysis, testing for the enrichment of association in co-expression networks. The aim of this ...
As universal expression is difficult to testify experimentally, a theoretical definition of HK genes based on annotated universal function is rather desirable. In order to build up a control gene set for a comparative analysis of microarray and EST data, we manually curated 408 genes — a comparab...
All too frequently, compounds that are potent inhibitors of enzymes in vitro ultimately fail to confirm against the whole organism because, among other reasons, they do not pass the cell membrane. Table 1. Advantages and disadvantages of the different drug screening approaches In vitro screening ...
How to decide which are the most pertinent overly-represented features during gene set enrichment analysis The search for enriched features has become widely used to characterize a set of genes or proteins. A key aspect of this technique is its ability to identi... R Barriot,DJ Sherman,I Du...
We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
to systematically evaluate the performance on gene expression data [25,26]. However, due to the diversity of the data domain, a recent work concluded that the choice of a clustering algorithm might depend on the specific experiment [26]. In the case of time series analysis, it has been ...