Patients were randomly assigned to either continue their usual course of treatment or begin taking a polypill instead. The polypill that was provided contained 100 milligrams of aspirin, 2.5, 5, or 10 milligrams of the ACE inhibitor ramipril, and 20 or 40 mg of atorvastatin. "The concept is...
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Inhibition of the renin–angiotensin–aldosterone system (RAAS) reduces the rate of progression of cardiovascular and renal disease in patients with established cardiac or renal dysfunction. The RAAS is complex with both autocrine, paracrine, and endocrine effects and there are multiple locations in thi...