How to dose vancomycin: Time to go Bayesian?doi:10.1016/j.ijantimicag.2021.106420.32Jennifer LeElsevier BVInternational Journal of Antimicrobial Agents
The recommendations from each formulary were used to calculate doses for each simulated child. Equivalence and difference in calculated doses were analysed. Results In total, dosing recommendations for 34 anti-infective substances were collected with 74 corresponding indications, which resulted in 47,...
To calculate the maximal antibi- otic dosage, body weight and length, as well as renal and Iiver function, must be known preoperatively. Preoperative imaging of the exact localization of the infection is important for planning the operative procedure. Radiographs may be made in four planes, and...
21 Mechanical ventilation should be managed the same as for a young adult, using ARDSnet criteria to calculate predicted body weight to optimize tidal volumes at 4 to 8 mL/kg.22 Common PICU Diagnoses The admitting diagnosis and comorbidities of the ill child in the PICU will play a major ...
(MRSA) infections is vancomycin, which continues to be the reference standard approach in this context. However, an increasing number of MRSA isolates with high MICs, within the susceptible range (vancomycin MIC creep), are being reported worldwide. It has been reported that the efficacy of vanc...
Aminoglycosides, fluoroquinolones, and vancomycin can be added if resistance is suspected or complications arise. Empirical antifungal coverage should be included if the patient remains febrile or hemodynamically unstable after 4–7 days with negative blood cultures. The antimicrobial regimen should include ...