is a common task performed by microbiologists. The number of bacteria in a clinical sample serves as an indication of the extent of an infection. Quality control of drinking water, food, medication, and even cosmetics relies on estimates of bacterial counts to detect contamination and prevent the...
We next asked how it is possible that long-lived misfolded proteins are able to bypass the post-translational cellular chaperone machinery. To address this question we used coarse-grained Langevin dynamics to calculate the dissociation constant between the chaperone GroEL and three distinct conformational...
Empty CellDefinitionHow to measure and calculateRemarks and explanation Accuracy The proportion of new tests that give correct results as the reference standard (both positive and negative). (Correct positive + correct negative)/total number [29]. Kappa A statistic method to measure agreement between...
Now, the latter two classes of parameters enable us to quantify the overall model plausibility (MP). The procedure is a constrained optimization problem with different strengths of ‘rubber-bands’ applying to class I–III model parameters. Here the objective function (f) to be minimized is the...
"Does your climate model predict the right precipitation pattern 400,000 years ago?" asked Mueller. "Using our data, modelers can calculate back in time to see if their model is right. That is one of the key things that we can provide." ...
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