R. et al. Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner. Proc. Natl Acad. Sci. USA 116, 8380–8389 (2019). Article CAS PubMed PubMed Central Google Scholar Parsons, R. Discovery of the PTEN tumor suppressor and its connection to the PI3K and AKT ...
The tumour suppressor gene TP53 is mutated in ~50% of human cancers. In addition to its function in tumour suppression, p53 also plays a major role in the response of malignant as well as nontransformed cells to many anticancer therapeutics, particularly those that cause DNA damage. P53 forms...
Myeloid-derived suppressor cells (MDSC) are present in most cancer patients where they are significant contributors to the immune suppressive tumor microenvironment (TME). The TME is a hostile locale due to deficiencies in oxygen (hypoxia) and nutrients, and the presence of reactive oxygen species ...
However, only in recent years has it been found that an excess of calcium ions not only contributes to the activation of proteolytic enzymes (for review see [26]) and the regulation of expression of a number of key genes, including isoforms of MyHC [27], but also par...
to upgrade, then hit the Actions button on the lower right of the screen. Select Upgrade, and this will apply the Orokin Reactor from your collection of fully built Orokin Reactors in your Inventory. If you do not have one built, you will be given the option to buy one for 20 Platinum...
An important challenge in cancer biology is to understand the complex aspects of the disease. It is increasingly evident that genes are not isolated from each other and the comprehension of how different genes are related to each other could explain biol
Besides mRNAs, host cells also express a variety of noncoding RNAs, including small RNAs, that may also be subject to inhibition upon viral infection. In this review we focused on different ways viruses antagonize coding and noncoding RNAs in the host cell to its advantage. Keywords: mRNA; ...
Introduction Lectins are widespread proteins in all kingdoms of life and have been identified as carbohydrate-binding proteins for a long time [1]. Their capability to selectively recognize and bind reversibly to specific mono- or oligosaccharides is the main feature of these proteins. Also, to be...
Can a Virginia resident sell a handgun to an active-duty military person living in Maryland but with a North Carolina driver's license? wikiHow Staff Editor Staff Answer Yes, but you'd have to go through an FFL dealer. All private sales in Virginia require the buyer to complete a backgro...
Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, Levine AJ and Pavletich NP (1996) Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274: 948–953. CAS PubMed Google Scholar Schon O, Friedler A, Bycroft M, Freund SM and Fersht ...