However, clinical genomic sequencing produces large amounts of data, much of which is hard to characterize or may have a negligible influence on health. Thus, one of the first questions that these programs face regards actionability: how to assess which types of genomic data have enough ...
An EPD is a certificate for a construction product that is based on its Life Cycle Assessment (LCA). This paper investigates potential solutions to direct end-users' awareness of environmental and health effects of the products they purchase. Therefore, two questionnaire surveys are held on ...
1. Introduction Presently, the robust development of global agriculture is challenged by a growing population, degraded farmland, and serious environmental issues, especially those related to climate change [1]. Since 2020, the COVID-19 pandemic and the fertilizer crisis have exacerbated soil ...
Therefore, the environmental conditions, such as the seawater temperature or the availability of nutrients, are expected to influence the sponge metabolism, and assessment of their impact on the biosynthesis and concentrations of specialized metabolites is of high relevance in the context of sponge ...
In a traditional supply chain, the objective of improving energy efficiency is targeted at the level of single parts of the value making chain. Industry 4.0 technologies make it possible to build hyperconnected logistic solutions, where the objective of decreasing energy consumption and economic foot...
The open innovation (OI) concept has changed the traditional, vertically-integrated mode for internally developed output, to achieve a new paradigm of innovation based on collaboration with several actors from outside the firm boundaries [4–12]. There are different partners that can be involved ...
Thus, this study aims at developing a refined procedure to measure SD-relevant procedural knowledge and to define a measure for such knowledge, including a suitable benchmark for its evaluation. As SD-relevant knowledge, the SD challenges biodiversity loss and climate change were focused on. For ...
The fifth assessment report (AR5) of the Intergovernmental Panel on Climate Change (IPCC) leaves us in no doubt that the climate changes that are now upon us are mainly due to anthropogenic emissions of greenhouse gasses (GHGs) [7]. The emissions from agriculture, forestry and other land ...
In other words, the roles of drivers and responses are not clearly separated: what started as being a response to a certain driver, may at a certain point affect the driver, therewith becoming a driver itself. Such two-way influences are generally called feedbacks. A general definition of ...
Introduction Fragment-based drug discovery (FBDD) has been developed in the past twenty years as an approach to derive novel lead compounds for various therapeutic targets [1–4]. It features the use of fragment-sized compounds that mostly comply with the 'Rule-of-3 [5] for the ...