What: AD is uniquely human, but molecular mechanisms can be measured in Tg mice. • Who: A universal biological variable of AD, APOE is critical for preclinical models. • How: There are several strategies for developing APOE-Tg mice. • When/Where: Developmental and region-specific mode...
The pace of exome and genome sequencing is accelerating, with the identification of many new disease-causing mutations in research settings, and it is likely that whole exome or genome sequencing could have a major impact in the clinical arena in the rel
The skin is the interface between the organism and the external environment, acting as its first barrier. Thus, this organ is constantly challenged by physical stimuli such as UV and infrared radiation, visible light, and temperature as well as chemicals and pathogens. To counteract the deleterious...
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