Pethidine was used for this intent, but is no longer recommended, because of the accumulation of a neurotoxic metabolite.8 Morphine, oxycodone, and hydromorphone are effective drugs for pain management. Each of these could be the first choice of drug in personalized treatment...
so their efficacy is questionable. However, the Russian chemists found a way to create GABA-like supplements that can cross the BBB and function like GABA in the brain.